SSE/EFI Working Paper Series in Economics and Finance
Linus Jönsson, Fredrik Borgström
Cost-Effectiveness of Alendronate in the Treatment of Osteoporosis in Denmark - An Economic Evaluation Based on the Fracture Intervention Trial
() and Niklas Zethraeus
Abstract: Background: The Fracture Intervention Trial (FIT) showed
that the bisphosphonate alendronate reduces the risk of fractures in women
with low bone mass in the United States.
Objective: To estimate the
cost-effectiveness (cost per life-year gained and cost per quality-adjusted
life-year, QALY, gained) of treating osteoporotic women in Denmark with
alendronate, compared with no treatment.
Design: A Markov model earlier
used in the economic evaluation for Sweden was adapted using
epidemiological and cost data for Denmark. In the base-case alendronate was
assumed to have a fracture-risk reducing effect for ten years; a treatment
duration period of 5 years followed by a 5-year period where the effect
declined linearly to zero.
Results: Treating a 71-year old (the mean
age in the vertebral arm of the FIT) osteoporotic woman with one prior
vertebral fracture with alendronate was found to be associated with a cost
of DKK 52,311 per QALY gained. The cost-effectiveness ratio when treating a
69-year old woman with low bone mass and without previous vertebral
fractures was higher (DKK 205,816) but still within the limits of what can
be considered good value for money.
Conclusions: The results of this
study indicate that treatment with alendronate in Denmark is
cost-effective, provided the treatment is targeted towards high-risk
patients corresponding to the patient groups in the FIT study.
Keywords: osteoporosis; cost-effectiveness; quality of life; Markov models; acceptability curve; (follow links to similar papers)
JEL-Codes: I10; I19; (follow links to similar papers)
29 pages, May 21, 2002
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